NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice

Sensory nerves emanating from the dorsal root extensively innervate the surfaces of mammalian bone, a privileged location for the regulation of biomechanical signaling. Here, we show that NGF-TrkA signaling in skeletal sensory nerves is an early response to mechanical loading of bone and is required...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Tomlinson, Ryan E., Li, Zhi, Li, Zhu, Minichiello, Liliana, Riddle, Ryan C., Venkatesan, Arun, Clemens, Thomas L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422802/
https://ncbi.nlm.nih.gov/pubmed/28416686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701054114
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