NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice

Sensory nerves emanating from the dorsal root extensively innervate the surfaces of mammalian bone, a privileged location for the regulation of biomechanical signaling. Here, we show that NGF-TrkA signaling in skeletal sensory nerves is an early response to mechanical loading of bone and is required...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Tomlinson, Ryan E., Li, Zhi, Li, Zhu, Minichiello, Liliana, Riddle, Ryan C., Venkatesan, Arun, Clemens, Thomas L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2017
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422802/
https://ncbi.nlm.nih.gov/pubmed/28416686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701054114
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