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Effects of doxorubicin on cardiac muscle subsarcolemmal and intermyofibrillar mitochondria

Doxorubicin (DOX) is a highly effective chemotherapeutic used in the treatment of a broad spectrum of malignancies. However, clinical use of DOX is highly limited by cumulative and irreversible cardiomyopathy that occurs following DOX treatment. The pathogenesis of DOX-induced cardiac muscle dysfunc...

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Detalhes bibliográficos
Publicado no:Mitochondrion
Main Authors: Kavazis, Andreas N., Morton, Aaron B., Hall, Stephanie E., Smuder, Ashley J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422146/
https://ncbi.nlm.nih.gov/pubmed/27832997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mito.2016.10.008
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