MiR-124-3p attenuates hyperphosphorylation of tau protein-induced apoptosis via caveolin-1-PI3K/Akt/GSK3β pathway in N2a/APP695swe cells

Hyperphosphorylation of Tau forming neurofibrillary tangles has been considered as a crucial event in the pathogenesis of Alzheimer's disease (AD). MiR-124-3p belongs to microRNA (miRNA) family and was markedly decreased in AD, however, the functions of miR-124-3p in the pathogenesis of AD rema...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Kang, Qingmei, Xiang, Yue, Li, Dan, Liang, Jie, Zhang, Xiong, Zhou, Fanlin, Qiao, Mengyuan, Nie, Yingling, He, Yurong, Cheng, Jingyi, Dai, Yubing, Li, Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5421849/
https://ncbi.nlm.nih.gov/pubmed/28186985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15149
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