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Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase
A complex interplay of environmental factors impacts the metabolism of human cells, but neither traditional culture media nor mouse plasma mimic the metabolite composition of human plasma. Here, we developed a culture medium with polar metabolite concentrations comparable to those of human plasma (h...
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| Udgivet i: | Cell |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5421364/ https://ncbi.nlm.nih.gov/pubmed/28388410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.03.023 |
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