Dipeptidyl peptidase-4 (DPP-4) inhibition with linagliptin reduces western diet-induced myocardial TRAF3IP2 expression, inflammation and fibrosis in female mice

BACKGROUND: Diastolic dysfunction (DD), a hallmark of obesity and primary defect in heart failure with preserved ejection fraction, is a predictor of future cardiovascular events. We previously reported that linagliptin, a dipeptidyl peptidase-4 inhibitor, improved DD in Zucker Obese rats, a genetic...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cardiovasc Diabetol
Auteurs principaux: Aroor, Annayya R., Habibi, Javad, Kandikattu, Hemanth Kumar, Garro-Kacher, Mona, Barron, Brady, Chen, Dongqing, Hayden, Melvin R., Whaley-Connell, Adam, Bender, Shawn B., Klein, Thomas, Padilla, Jaume, Sowers, James R., Chandrasekar, Bysani, DeMarco, Vincent G.
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2017
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420102/
https://ncbi.nlm.nih.gov/pubmed/28476142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-017-0544-4
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