Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-related Macular Degeneration

Age-related macular degeneration (AMD) affects the retinal pigment epithelium (RPE), a cell monolayer essential for photoreceptor survival, and is the leading cause of vision loss in the elderly. There are no disease-altering therapies for dry AMD, which is characterized by accumulation of subretina...

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Udgivet i:Cell Stem Cell
Main Authors: Saini, Janmeet S., Corneo, Barbara, Miller, Justine D., Kiehl, Thomas R., Wang, Qingjie, Boles, Nathan C., Blenkinsop, Timothy A., Stern, Jeffrey H., Temple, Sally
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419856/
https://ncbi.nlm.nih.gov/pubmed/28132833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.12.015
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