Interplay and Effects of Temporal Changes in the Phosphorylation State of Serine-302, -307, and -318 of Insulin Receptor Substrate-1 on Insulin Action in Skeletal Muscle Cells

Transduction of the insulin signal is mediated by multisite Tyr and Ser/Thr phosphorylation of the insulin receptor substrates (IRSs). Previous studies on the function of single-site phosphorylation, particularly phosphorylation of Ser-302, -307, and -318 of IRS-1, showed attenuating as well as enha...

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Publicado no:Mol Endocrinol
Main Authors: Weigert, Cora, Kron, Matthias, Kalbacher, Hubert, Pohl, Ann Kathrin, Runge, Heike, Häring, Hans-Ulrich, Schleicher, Erwin, Lehmann, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419409/
https://ncbi.nlm.nih.gov/pubmed/18927238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0102
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