Individual Stearoyl-CoA Desaturase 1 Expression Modulates Endoplasmic Reticulum Stress and Inflammation in Human Myotubes and Is Associated With Skeletal Muscle Lipid Storage and Insulin Sensitivity In Vivo

OBJECTIVE: Increased plasma levels of free fatty acids occur in obesity and type 2 diabetes and contribute to the development of insulin resistance. Saturated fatty acids (SFAs) such as palmitate especially have lipotoxic effects leading to endoplasmatic reticulum (ER) stress, inflammation, and insu...

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Autors principals: Peter, Andreas, Weigert, Cora, Staiger, Harald, Machicao, Fausto, Schick, Fritz, Machann, Jürgen, Stefan, Norbert, Thamer, Claus, Häring, Hans-Ulrich, Schleicher, Erwin
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2009
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712792/
https://ncbi.nlm.nih.gov/pubmed/19478146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0188
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