Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells

Inherent plasticity and various survival cues allow glioblastoma stem-like cells (GSCs) to survive and proliferate under intrinsic and extrinsic stress conditions. Here, we report that GSCs depend on the adaptive activation of ER stress and subsequent activation of lipogenesis and particularly stear...

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Detalhes bibliográficos
Publicado no:Stem Cell Reports
Main Authors: Pinkham, Kelsey, Park, David Jaehyun, Hashemiaghdam, Arsalan, Kirov, Aleksandar B., Adam, Isam, Rosiak, Kamila, da Hora, Cintia C., Teng, Jian, Cheah, Pike See, Carvalho, Litia, Ganguli-Indra, Gitali, Kelly, Avalon, Indra, Arup K., Badr, Christian E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6450460/
https://ncbi.nlm.nih.gov/pubmed/30930246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2019.02.012
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