Transmembrane TNF-dependent uptake of anti-TNF antibodies

TNF-α (TNF), a pro-inflammatory cytokine is synthesized as a 26 kDa protein, anchors in the plasma membrane as transmembrane TNF (TmTNF), and is subjected to proteolysis by the TNF-α converting enzyme (TACE) to release the 15 kDa form of soluble TNF (sTNF). TmTNF and sTNF interact with 2 distinct re...

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Pubblicato in:MAbs
Autori principali: Deora, Arun, Hegde, Subramanya, Lee, Jacqueline, Choi, Chee-Ho, Chang, Qing, Lee, Cheryl, Eaton, Lucia, Tang, Hua, Wang, Dongdong, Lee, David, Michalak, Mark, Tomlinson, Medha, Tao, Qingfeng, Gaur, Nidhi, Harvey, Bohdan, McLoughlin, Shaun, Labkovsky, Boris, Ghayur, Tariq
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2017
Soggetti:
Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419086/
https://ncbi.nlm.nih.gov/pubmed/28323513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1304869
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