Methotrexate Enhances Apoptosis of Transmembrane TNF-Expressing Cells Treated With Anti-TNF Agents

BACKGROUND: Concomitant use of methotrexate (MTX) improves the clinical efficacy of anti-TNF agents in the treatment of rheumatoid arthritis (RA). We aimed to clarify the cytotoxic effect of MTX on transmembrane TNF (tmTNF)-expressing cells treated with anti-TNF agents. METHODS: Jurkat T cells stabl...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Wang, Qiaolei, Oryoji, Daisuke, Mitoma, Hiroki, Kimoto, Yasutaka, Koyanagi, Masamichi, Yokoyama, Kana, Ayano, Masahiro, Akahoshi, Mitsuteru, Arinobu, Yojiro, Niiro, Hiroaki, Akashi, Koichi, Horiuchi, Takahiko
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456895/
https://ncbi.nlm.nih.gov/pubmed/32922407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02042
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