Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity

Targeted therapeutics that can differentiate between normal and malignant tumor cells represent the ideal standard for the development of a successful anti-cancer strategy. The Sialyl-Thomsen-nouveau antigen (STn or Sialyl-Tn, also known as CD175s) is rarely seen in normal adult tissues, but it is a...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Prendergast, Jillian M., Galvao da Silva, Ana Paula, Eavarone, David A., Ghaderi, Darius, Zhang, Mai, Brady, Dane, Wicks, Joan, DeSander, Julie, Behrens, Jeff, Rueda, Bo R.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419082/
https://ncbi.nlm.nih.gov/pubmed/28281872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1290752
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