Humanized anti-Sialyl-Tn antibodies for the treatment of ovarian carcinoma

The expression of Sialyl-Tn (STn) in tumors is associated with metastatic disease, poor prognosis, and reduced overall survival. STn is expressed on ovarian cancer biomarkers including CA-125 (MUC16) and MUC1, and elevated serum levels of STn in ovarian cancer patients correlate with lower five-year...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Eavarone, David A., Al-Alem, Linah, Lugovskoy, Alexey, Prendergast, Jillian M., Nazer, Rawan I., Stein, Jenna N., Dransfield, Daniel T., Behrens, Jeff, Rueda, Bo R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063429/
https://ncbi.nlm.nih.gov/pubmed/30052649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0201314
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