Additional rare variant analysis in Parkinson’s disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance

Oligogenic inheritance implies a role for several genetic factors in disease etiology. We studied oligogenic inheritance in Parkinson’s (PD) by assessing the potential burden of additional rare variants in established Mendelian genes and/or GBA, in individuals with and without a primary pathogenic g...

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Detalles Bibliográficos
Publicado en:Hum Mol Genet
Main Authors: Lubbe, Steven J., Escott-Price, Valentina, Gibbs, J. Raphael, Nalls, Mike A., Bras, Jose, Price, T. Ryan, Nicolas, Aude, Jansen, Iris E., Mok, Kin Y., Pittman, Alan M., Tomkins, James E., Lewis, Patrick A., Noyce, Alastair J., Lesage, Suzanne, Sharma, Manu, Schiff, Elena R., Levine, Adam P., Brice, Alexis, Gasser, Thomas, Hardy, John, Heutink, Peter, Wood, Nicholas W., Singleton, Andrew B., Williams, Nigel M., Morris, Huw R.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2016
Assuntos:
Association Studies Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418836/
https://ncbi.nlm.nih.gov/pubmed/27798102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw348
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