Additional rare variant analysis in Parkinson’s disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance

Oligogenic inheritance implies a role for several genetic factors in disease etiology. We studied oligogenic inheritance in Parkinson’s (PD) by assessing the potential burden of additional rare variants in established Mendelian genes and/or GBA, in individuals with and without a primary pathogenic g...

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Библиографические подробности
Опубликовано в: :Hum Mol Genet
Главные авторы: Lubbe, Steven J., Escott-Price, Valentina, Gibbs, J. Raphael, Nalls, Mike A., Bras, Jose, Price, T. Ryan, Nicolas, Aude, Jansen, Iris E., Mok, Kin Y., Pittman, Alan M., Tomkins, James E., Lewis, Patrick A., Noyce, Alastair J., Lesage, Suzanne, Sharma, Manu, Schiff, Elena R., Levine, Adam P., Brice, Alexis, Gasser, Thomas, Hardy, John, Heutink, Peter, Wood, Nicholas W., Singleton, Andrew B., Williams, Nigel M., Morris, Huw R.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Association Studies Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418836/
https://ncbi.nlm.nih.gov/pubmed/27798102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw348
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