IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas

BACKGROUND: Mutations in isocitrate dehydrogenase (IDH)1 or -2 are found in ~50% of conventional central chondrosarcomas and in up to 87% of their assumed benign precursors enchondromas. The mutant enzyme acquires the activity to convert α-ketoglutarate into the oncometabolite d-2-hydroxyglutarate (...

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Detalhes bibliográficos
Publicado no:Clin Sarcoma Res
Main Authors: Cleven, Arjen H. G., Suijker, Johnny, Agrogiannis, Georgios, Briaire-de Bruijn, Inge H., Frizzell, Norma, Hoekstra, Attje S., Wijers-Koster, Pauline M., Cleton-Jansen, Anne-Marie, Bovée, Judith V. M. G.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418698/
https://ncbi.nlm.nih.gov/pubmed/28484589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13569-017-0074-6
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