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Evidence that a mitochondrial death spiral underlies antagonistic pleiotropy
The antagonistic pleiotropy (AP) theory posits that aging occurs because alleles that are detrimental in older organisms are beneficial to growth early in life and thus are maintained in populations. Although genes of the insulin signaling pathway likely participate in AP, the insulin‐regulated cell...
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| Publicado no: | Aging Cell |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418193/ https://ncbi.nlm.nih.gov/pubmed/28185435 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12579 |
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