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Rac1 GTPase regulates 11β hydroxysteroid dehydrogenase type 2 and fibrotic remodeling
The aim of the study was to characterize the role of Rac1 GTPase for the mineralocorticoid receptor (MR)-mediated pro-fibrotic remodeling. Transgenic mice with cardiac overexpression of constitutively active Rac1 (RacET) develop an age-dependent phenotype with atrial dilatation, fibrosis, and atrial...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418052/ https://ncbi.nlm.nih.gov/pubmed/28320863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764449 |
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