Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of myelin itself. Surprisingly, nerves of Schwann...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kleinecke, Sandra, Richert, Sarah, de Hoz, Livia, Brügger, Britta, Kungl, Theresa, Asadollahi, Ebrahim, Quintes, Susanne, Blanz, Judith, McGonigal, Rhona, Naseri, Kobra, Sereda, Michael W, Sachsenheimer, Timo, Lüchtenborg, Christian, Möbius, Wiebke, Willison, Hugh, Baes, Myriam, Nave, Klaus-Armin, Kassmann, Celia Michèle
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417850/
https://ncbi.nlm.nih.gov/pubmed/28470148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23332
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