Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy

Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease mechanism and the finding that glial lipid metabolism is critical for axon function, independent of myelin itself. Surprisingly, nerves of Schwann...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Kleinecke, Sandra, Richert, Sarah, de Hoz, Livia, Brügger, Britta, Kungl, Theresa, Asadollahi, Ebrahim, Quintes, Susanne, Blanz, Judith, McGonigal, Rhona, Naseri, Kobra, Sereda, Michael W, Sachsenheimer, Timo, Lüchtenborg, Christian, Möbius, Wiebke, Willison, Hugh, Baes, Myriam, Nave, Klaus-Armin, Kassmann, Celia Michèle
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2017
Pynciau:
Neuroscience
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417850/
https://ncbi.nlm.nih.gov/pubmed/28470148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23332
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