Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes

Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), particularly when stimulated with proinflammatory cytokines. NO is involved in OA cartilage degradation. On the other hand, c-Jun N-terminal Kinase (J...

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Veröffentlicht in:PLoS One
Hauptverfasser: Bwalya, Eugene C., Kim, Sangho, Fang, Jing, Wijekoon, H. M. Suranji, Hosoya, Kenji, Okumura, Masahiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417682/
https://ncbi.nlm.nih.gov/pubmed/28472120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177144
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