Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes

Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), particularly when stimulated with proinflammatory cytokines. NO is involved in OA cartilage degradation. On the other hand, c-Jun N-terminal Kinase (J...

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發表在:PLoS One
Main Authors: Bwalya, Eugene C., Kim, Sangho, Fang, Jing, Wijekoon, H. M. Suranji, Hosoya, Kenji, Okumura, Masahiro
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417682/
https://ncbi.nlm.nih.gov/pubmed/28472120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177144
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