Pentosan polysulfate inhibits IL-1β-induced iNOS, c-Jun and HIF-1α upregulation in canine articular chondrocytes

Osteoarthritic (OA) chondrocytes are shown to express inducible nitric oxide synthase (iNOS) which produces high concentrations of nitric oxide (NO), particularly when stimulated with proinflammatory cytokines. NO is involved in OA cartilage degradation. On the other hand, c-Jun N-terminal Kinase (J...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Bwalya, Eugene C., Kim, Sangho, Fang, Jing, Wijekoon, H. M. Suranji, Hosoya, Kenji, Okumura, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417682/
https://ncbi.nlm.nih.gov/pubmed/28472120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0177144
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