Orphan Receptor TR3 Enhances p53 Transactivation and Represses DNA Double-Strand Break Repair in Hepatoma Cells under Ionizing Radiation

In response to ionizing radiation (IR)-induced DNA double-strand breaks (DSB), cells elicit an evolutionarily conserved checkpoint response that induces cell cycle arrest and either DNA repair or apoptosis, thereby maintaining genomic stability. DNA-dependent protein kinase (DNA-PK) is a central enz...

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Detalhes bibliográficos
Publicado no:Mol Endocrinol
Main Authors: Zhao, Bi-xing, Chen, Hang-zi, Du, Xiao-dan, Luo, Jie, He, Jian-ping, Wang, Rong-hao, Wang, Yuan, Wu, Rong, Hou, Ru-rong, Hong, Ming, Wu, Qiao
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417243/
https://ncbi.nlm.nih.gov/pubmed/21659476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-0081
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