Increased DNA Methylation and Decreased Expression of PDX-1 in Pancreatic Islets from Patients with Type 2 Diabetes

Mutations in pancreatic duodenal homeobox 1 (PDX-1) can cause a monogenic form of diabetes (maturity onset diabetes of the young 4) in humans, and silencing Pdx-1 in pancreatic β-cells of mice causes diabetes. However, it is not established whether epigenetic alterations of PDX-1 influence type 2 di...

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Publicat a:Mol Endocrinol
Autors principals: Yang, Beatrice T., Dayeh, Tasnim A., Volkov, Petr A., Kirkpatrick, Clare L., Malmgren, Siri, Jing, Xingjun, Renström, Erik, Wollheim, Claes B., Nitert, Marloes Dekker, Ling, Charlotte
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416998/
https://ncbi.nlm.nih.gov/pubmed/22570331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1004
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