Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells

We previously demonstrated that long-term pretreatment of rat FRTL-5 thyroid cells with TSH or cAMP-generating reagents potentiated IGF-I-dependent DNA synthesis. Under these conditions, cAMP treatment increased tyrosine phosphorylation of a 125-kDa protein (p125) and its association with a p85 regu...

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Vydáno v:Mol Endocrinol
Hlavní autoři: Yamanaka, Daisuke, Akama, Takeshi, Fukushima, Toshiaki, Nedachi, Taku, Kawasaki, Chie, Chida, Kazuhiro, Minami, Shiro, Suzuki, Koichi, Hakuno, Fumihiko, Takahashi, Shin-Ichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2012
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416991/
https://ncbi.nlm.nih.gov/pubmed/22496359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1349
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