Paraquat-induced Oxidative Stress Represses Phosphatidylinositol 3-Kinase Activities Leading to Impaired Glucose Uptake in 3T3-L1 Adipocytes

Accumulated evidence indicates that oxidative stress causes and/or promotes insulin resistance; however, the mechanism by which this occurs is not fully understood. This study was undertaken to elucidate the molecular mechanism by which oxidative stress induced by paraquat impairs insulin-dependent...

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Detalhes bibliográficos
Main Authors: Shibata, Michihiro, Hakuno, Fumihiko, Yamanaka, Daisuke, Okajima, Hiroshi, Fukushima, Toshiaki, Hasegawa, Takashi, Ogata, Tomomi, Toyoshima, Yuka, Chida, Kazuhiro, Kimura, Kumi, Sakoda, Hideyuki, Takenaka, Asako, Asano, Tomoichiro, Takahashi, Shin-Ichiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898352/
https://ncbi.nlm.nih.gov/pubmed/20430890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.126482
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