Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Maintaining genome integrity is important for cells and damaged DNA triggers autoimmunity. Previous studies have reported that Three-prime repair exonuclease 1(TREX1), an endogenous DNA exonuclease, prevents immune activation by depleting damaged DNA, thus preventing the development of certain autoi...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Li, Peng, Du, Juan, Goodier, John L., Hou, Jingwei, Kang, Jian, Kazazian, Haig H., Zhao, Ke, Yu, Xiao-Fang
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2017
Materias:
Molecular Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416883/
https://ncbi.nlm.nih.gov/pubmed/28334850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx178
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares