Aicardi–Goutières syndrome protein TREX1 suppresses L1 and maintains genome integrity through exonuclease-independent ORF1p depletion

Maintaining genome integrity is important for cells and damaged DNA triggers autoimmunity. Previous studies have reported that Three-prime repair exonuclease 1(TREX1), an endogenous DNA exonuclease, prevents immune activation by depleting damaged DNA, thus preventing the development of certain autoi...

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Foilsithe in:Nucleic Acids Res
Main Authors: Li, Peng, Du, Juan, Goodier, John L., Hou, Jingwei, Kang, Jian, Kazazian, Haig H., Zhao, Ke, Yu, Xiao-Fang
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2017
Ábhair:
Molecular Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5416883/
https://ncbi.nlm.nih.gov/pubmed/28334850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx178
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