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PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice
BACKGROUND: Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27me3, which marks many transcriptionally silent genes throughout the mammalian genome. Although H3K27me3 is associated with silenced gene expression broadly, it remains unclear why some but not other PRC2 target genes require PRC...
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| Publié dans: | Genome Biol |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2017
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5415793/ https://ncbi.nlm.nih.gov/pubmed/28468635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1211-5 |
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