PRC2 represses transcribed genes on the imprinted inactive X chromosome in mice

BACKGROUND: Polycomb repressive complex 2 (PRC2) catalyzes histone H3K27me3, which marks many transcriptionally silent genes throughout the mammalian genome. Although H3K27me3 is associated with silenced gene expression broadly, it remains unclear why some but not other PRC2 target genes require PRC...

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Bibliografiske detaljer
Udgivet i:Genome Biol
Main Authors: Maclary, Emily, Hinten, Michael, Harris, Clair, Sethuraman, Shriya, Gayen, Srimonta, Kalantry, Sundeep
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415793/
https://ncbi.nlm.nih.gov/pubmed/28468635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-017-1211-5
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