A New Strategy for Selective Targeting of Progesterone Receptor With Passive Antagonists

Currently available progesterone (P4) receptor (PR) antagonists, such as mifepristone (RU486), lack specificity and display partial agonist properties, leading to potential drawbacks in their clinical use. Recent x-ray crystallographic studies have identified key contacts involved in the binding of...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Endocrinol
Main Authors: Khan, Junaid A., Tikad, Abdellatif, Fay, Michel, Hamze, Abdallah, Fagart, Jérôme, Chabbert-Buffet, Nathalie, Meduri, Geri, Amazit, Larbi, Brion, Jean-Daniel, Alami, Mouad, Lombès, Marc, Loosfelt, Hugues, Rafestin-Oblin, Marie-Edith
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2013
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415273/
https://ncbi.nlm.nih.gov/pubmed/23579486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1328
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