Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1

Aldosterone regulates sodium homeostasis by activating the mineralocorticoid receptor (MR), a member of the nuclear receptor superfamily. Hyperaldosteronism leads todeleterious effects on the kidney, blood vessels, and heart. Although steroidal antagonists such as spironolactone and eplerenone are c...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Amazit, Larbi, Le Billan, Florian, Kolkhof, Peter, Lamribet, Khadija, Viengchareun, Say, Fay, Michel R., Khan, Junaid A., Hillisch, Alexander, Lombès, Marc, Rafestin-Oblin, Marie-Edith, Fagart, Jérôme
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4571943/
https://ncbi.nlm.nih.gov/pubmed/26203193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.657957
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