A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule

Limitations of current steroidal mineralocorticoid receptor (MR) antagonists have stimulated the search for a new generation of molecules. We screened for novel nonsteroidal compounds and identified MR antagonists derived from the chemical class of dihydropyridines. Chemical optimization resulted in...

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Main Authors: Fagart, Jérôme, Hillisch, Alexander, Huyet, Jessica, Bärfacker, Lars, Fay, Michel, Pleiss, Ulrich, Pook, Elisabeth, Schäfer, Stefan, Rafestin-Oblin, Marie-Edith, Kolkhof, Peter
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2943305/
https://ncbi.nlm.nih.gov/pubmed/20650892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.131342
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