Ligand-Dependent Degradation of SRC-1 Is Pivotal for Progesterone Receptor Transcriptional Activity

The progesterone receptor (PR), a ligand-activated transcription factor, recruits the primary coactivator steroid receptor coactivator-1 (SRC-1) gene promoters. It is known that PR transcriptional activity is paradoxically coupled to its ligand-dependent down-regulation. However, despite its importa...

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Detalhes bibliográficos
Main Authors: Amazit, Larbi, Roseau, Audrey, Khan, Junaid A., Chauchereau, Anne, Tyagi, Rakesh K., Loosfelt, Hugues, Leclerc, Philippe, Lombès, Marc, Guiochon-Mantel, Anne
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320859/
https://ncbi.nlm.nih.gov/pubmed/21273440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0458
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