CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes

CD69 is an early activation marker on the surface of T lymphocytes undergoing activation by cognate antigen. We observed intense expression of CD69 on tumor-infiltrating T-lymphocytes that reside in the hypoxic tumor microenvironment and hypothesized that CD69 could be, at least partially, under the...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Labiano, Sara, Meléndez-Rodríguez, Florinda, Palazón, Asís, Teijeira, Álvaro, Garasa, Saray, Etxeberria, Iñaki, Aznar, M. Ángela, Sánchez-Paulete, Alfonso R., Azpilikueta, Arantza, Bolaños, Elixabet, Molina, Carmen, de la Fuente, Hortensia, Maiso, Patricia, Sánchez-Madrid, Francisco, de Landázuri, Manuel Ortiz, Aragonés, Julián, Melero, Ignacio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414881/
https://ncbi.nlm.nih.gov/pubmed/28507790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2017.1283468
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