Anti-LPS antibodies protect against Klebsiella pneumoniae by empowering neutrophil-mediated clearance without neutralizing TLR4

Initial promising results with immune sera guided early human mAb approaches against Gram-negative sepsis to an LPS neutralization mechanism, but these efforts failed in human clinical trials. Emergence of multidrug resistance has renewed interest in pathogen-specific mAbs. We utilized a pair of ant...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Cohen, Taylor S., Pelletier, Mark, Cheng, Lily, Pennini, Meghan E., Bonnell, Jessica, Cvitkovic, Romana, Chang, Chew-shun, Xiao, Xiaodong, Cameroni, Elisabetta, Corti, Davide, Semenova, Elena, Warrener, Paul, Sellman, Bret R., Suzich, JoAnn, Wang, Qun, Stover, C. Kendall
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414560/
https://ncbi.nlm.nih.gov/pubmed/28469079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92774
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