Chronic Endurance Exercise Impairs Cardiac Structure and Function in Middle-Aged Mice with Impaired Nrf2 Signaling

Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling maintains the redox homeostasis and its activation is shown to suppress cardiac maladaptation. Earlier we reported that acute endurance exercise (2 days) evoked antioxidant cytoprotection in young WT animals but not in aged WT animals. How...

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Udgivet i:Front Physiol
Main Authors: Shanmugam, Gobinath, Narasimhan, Madhusudhanan, Conley, Robbie L., Sairam, Thiagarajan, Kumar, Ashutosh, Mason, Ronald P., Sankaran, Ramalingam, Hoidal, John R., Rajasekaran, Namakkal S.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413495/
https://ncbi.nlm.nih.gov/pubmed/28515695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00268
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