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Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions
Microhomology (MH) flanking a DNA double-strand break (DSB) drives chromosomal rearrangements but its role in mutagenesis has not yet been analyzed. Here we determined the mutation frequency of a URA3 reporter gene placed at multiple locations distal to a DSB, which is flanked by different sizes (15...
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| Publicado en: | PLoS Genet |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5413072/ https://ncbi.nlm.nih.gov/pubmed/28419093 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006714 |
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