Microhomology-mediated end joining induces hypermutagenesis at breakpoint junctions

Microhomology (MH) flanking a DNA double-strand break (DSB) drives chromosomal rearrangements but its role in mutagenesis has not yet been analyzed. Here we determined the mutation frequency of a URA3 reporter gene placed at multiple locations distal to a DSB, which is flanked by different sizes (15...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Sinha, Supriya, Li, Fuyang, Villarreal, Diana, Shim, Jae Hoon, Yoon, Suhyeon, Myung, Kyungjae, Shim, Eun Yong, Lee, Sang Eun
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413072/
https://ncbi.nlm.nih.gov/pubmed/28419093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006714
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