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Shaping proteostasis at the cellular, tissue, and organismal level

The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases. In multicellular organisms, the PN is regulated at the cellular, tissue, and...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Sala, Ambre J., Bott, Laura C., Morimoto, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412572/
https://ncbi.nlm.nih.gov/pubmed/28400444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201612111
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