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Both R-loop removal and ribonucleotide excision repair activities of RNase H2 contribute substantially to chromosome stability
Cells carrying deletions of genes encoding H-class ribonucleases display elevated rates of chromosome instability. The role of these enzymes is to remove RNA-DNA associations including persistent mRNA-DNA hybrids (R-loops) formed during transcription, and ribonucleotides incorporated into DNA during...
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| Gepubliceerd in: | DNA Repair (Amst) |
|---|---|
| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412515/ https://ncbi.nlm.nih.gov/pubmed/28268090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2017.02.012 |
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