DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation

The molecular determinants of muscle progenitor impairment to regenerate aged muscles are currently unclear. We show that, in a mouse model of replicative senescence, decline in muscle satellite cell-mediated regeneration coincides with activation of DNA damage response (DDR) and impaired ability to...

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Bibliographische Detailangaben
Veröffentlicht in:Genes Dev
Hauptverfasser: Latella, Lucia, Dall'Agnese, Alessandra, Sesillo, Francesca Boscolo, Nardoni, Chiara, Cosentino, Marianna, Lahm, Armin, Sacco, Alessandra, Puri, Pier Lorenzo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411706/
https://ncbi.nlm.nih.gov/pubmed/28446595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.293266.116
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