DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation

The molecular determinants of muscle progenitor impairment to regenerate aged muscles are currently unclear. We show that, in a mouse model of replicative senescence, decline in muscle satellite cell-mediated regeneration coincides with activation of DNA damage response (DDR) and impaired ability to...

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Bibliographic Details
Published in:Genes Dev
Main Authors: Latella, Lucia, Dall'Agnese, Alessandra, Sesillo, Francesca Boscolo, Nardoni, Chiara, Cosentino, Marianna, Lahm, Armin, Sacco, Alessandra, Puri, Pier Lorenzo
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2017
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411706/
https://ncbi.nlm.nih.gov/pubmed/28446595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.293266.116
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