DNA damage signaling mediates the functional antagonism between replicative senescence and terminal muscle differentiation

The molecular determinants of muscle progenitor impairment to regenerate aged muscles are currently unclear. We show that, in a mouse model of replicative senescence, decline in muscle satellite cell-mediated regeneration coincides with activation of DNA damage response (DDR) and impaired ability to...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Latella, Lucia, Dall'Agnese, Alessandra, Sesillo, Francesca Boscolo, Nardoni, Chiara, Cosentino, Marianna, Lahm, Armin, Sacco, Alessandra, Puri, Pier Lorenzo
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411706/
https://ncbi.nlm.nih.gov/pubmed/28446595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.293266.116
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