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Targeting the MDM2–p53 Protein–Protein Interaction for New Cancer Therapy: Progress and Challenges
MDM2 is a primary cellular inhibitor of p53. It inhibits p53 function by multiple mechanisms, each of which, however, is mediated by their direct interaction. It has been proposed that small-molecule inhibitors designed to block the MDM2–p53 interaction may be effective in the treatment of human can...
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| Udgivet i: | Cold Spring Harb Perspect Med |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5411684/ https://ncbi.nlm.nih.gov/pubmed/28270530 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026245 |
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