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PIK3CA-Mutated Melanoma Cells Rely on Cooperative Signaling through mTORC1/2 for Sustained Proliferation
Malignant conversion of BRAF- or NRAS-mutated melanocytes into melanoma cells can be promoted by PI3’-lipid signaling. Using human NRAS- or BRAF-mutated melanoma cells that co-express mutationally activated PIK3CA, we explored the contribution of PI3′-lipid signaling to cell proliferation. Despite m...
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| Udgivet i: | Pigment Cell Melanoma Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5411292/ https://ncbi.nlm.nih.gov/pubmed/28233937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12586 |
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