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Aggregation landscapes of Huntingtin exon 1 protein fragments and the critical repeat length for the onset of Huntington’s disease

Huntington’s disease (HD) is a neurodegenerative disease caused by an abnormal expansion in the polyglutamine (polyQ) track of the Huntingtin (HTT) protein. The severity of the disease depends on the polyQ repeat length, arising only in patients with proteins having 36 repeats or more. Previous stud...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Chen, Mingchen, Wolynes, Peter G.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410817/
https://ncbi.nlm.nih.gov/pubmed/28400517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1702237114
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