Kinetin Riboside and Its ProTides Activate the Parkinson’s Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization

[Image: see text] Since loss of function mutations of PINK1 lead to early onset Parkinson’s disease, there has been growing interest in the discovery of small molecules that amplify the kinase activity of PINK1. We herein report the design, synthesis, serum stability, and hydrolysis of four kinetin...

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Bibliografiska uppgifter
I publikationen:J Med Chem
Huvudupphovsmän: Osgerby, Laura, Lai, Yu-Chiang, Thornton, Peter J., Amalfitano, Joseph, Le Duff, Cécile S., Jabeen, Iqra, Kadri, Hachemi, Miccoli, Ageo, Tucker, James H. R., Muqit, Miratul M. K., Mehellou, Youcef
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2017
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410652/
https://ncbi.nlm.nih.gov/pubmed/28323427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01897
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