PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines

B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph(+)) B-ALL is a subtype that expresses the Bcr-Abl fusion protein which represents a negative prognostic factor. Constitutive activati...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ultimo, Simona, Simioni, Carolina, Martelli, Alberto M., Zauli, Giorgio, Evangelisti, Camilla, Celeghini, Claudio, McCubrey, James A., Marisi, Giorgia, Ulivi, Paola, Capitani, Silvano, Neri, Luca M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410298/
https://ncbi.nlm.nih.gov/pubmed/28390196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15542
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