Triple Akt inhibition as a new therapeutic strategy in T-cell acute lymphoblastic leukemia

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive neoplastic disorder in which chemotherapy resistance and refractory relapses occur, with a poorer prognostic outcome. Constitutively active PI3K/Akt/mTOR pathway is a common feature of T-ALL upregulating cell proliferation, survival and dr...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Cani, Alice, Simioni, Carolina, Martelli, Alberto M., Zauli, Giorgio, Tabellini, Giovanna, Ultimo, Simona, McCubrey, James A., Capitani, Silvano, Neri, Luca M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466637/
https://ncbi.nlm.nih.gov/pubmed/25788264
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