Synergistic effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway or NUP214-ABL1 fusion protein in human Acute Lymphoblastic Leukemia

Philadelphia chromosome-positive (Ph+) Acute Lymphoblastic Leukemia (ALL) accounts for 25–30% of adult ALL and its incidence increases with age in adults >40 years old. Irrespective of age, the ABL1 fusion genes are markers of poor prognosis and amplification of the NUP214-ABL1 oncogene can be de...

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Foilsithe in:Oncotarget
Main Authors: Simioni, Carolina, Ultimo, Simona, Martelli, Alberto M., Zauli, Giorgio, Milani, Daniela, McCubrey, James A., Capitani, Silvano, Neri, Luca M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5346755/
https://ncbi.nlm.nih.gov/pubmed/27821800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13035
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