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Structure and allosteric inhibition of excitatory amino acid transporter 1

Human members of the solute carrier 1 (SLC1) family of transporters take up excitatory neurotransmitters in the brain and amino acids in peripheral organs. Dysregulation of their functions is associated to neurodegenerative disorders and cancer. Here we present the first crystal structures of a ther...

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Bibliografski detalji
Izdano u:Nature
Glavni autori: Canul-Tec, Juan C., Assal, Reda, Cirri, Erica, Legrand, Pierre, Brier, Sébastien, Chamot-Rooke, Julia, Reyes, Nicolas
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410168/
https://ncbi.nlm.nih.gov/pubmed/28424515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22064
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